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2020 | OriginalPaper | Buchkapitel

12. Diabetesformen bei Kindern und Jugendlichen

verfasst von : Olga Kordonouri, Klemens Raile

Erschienen in: Pädiatrische Endokrinologie und Diabetologie

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Diabetes mellitus ist eine Stoffwechselerkrankung charakterisiert durch eine chronische Hyperglykämie als Resultat einer fehlenden Insulinsekretion, einer gestörten Insulinwirkung oder von beidem. Eine eindeutige Zuordnung der Diabetesform ist für Betroffene von hoher prognostischer und therapeutischer Relevanz.
Literatur
Zurück zum Zitat Achenbach P, Warncke K, Reiter J et al (2004) Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53:384–389PubMedCrossRef Achenbach P, Warncke K, Reiter J et al (2004) Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53:384–389PubMedCrossRef
Zurück zum Zitat Achenbach P, Bonifacio E, Koczwara K, Ziegler AG (2005) Natural history of type 1 diabetes. Diabetes 54(2):25–31CrossRef Achenbach P, Bonifacio E, Koczwara K, Ziegler AG (2005) Natural history of type 1 diabetes. Diabetes 54(2):25–31CrossRef
Zurück zum Zitat American Diabetes Association (2000) Type 2 diabetes in children and adolescents. Diabetes Care 23:381–389CrossRef American Diabetes Association (2000) Type 2 diabetes in children and adolescents. Diabetes Care 23:381–389CrossRef
Zurück zum Zitat American Diabetes Association (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Suppl 1):S81–S90CrossRef American Diabetes Association (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Suppl 1):S81–S90CrossRef
Zurück zum Zitat American Diabetes Association (2018) Classification and diagnosis of diabetes: standards of medical care in diabetes 2018. Diabetes Care 41(Suppl 1):S13–S27CrossRef American Diabetes Association (2018) Classification and diagnosis of diabetes: standards of medical care in diabetes 2018. Diabetes Care 41(Suppl 1):S13–S27CrossRef
Zurück zum Zitat Bastra MR, Aanstoot HJ, Herbrink P (2001) Prediction and diagnosis of type 1 diabetes using b-cell autoantibodies. Clin Lab 47:497–507 Bastra MR, Aanstoot HJ, Herbrink P (2001) Prediction and diagnosis of type 1 diabetes using b-cell autoantibodies. Clin Lab 47:497–507
Zurück zum Zitat Becker M, Galler A, Raile K (2014) Meglitinide analogues in adolescent patients with HNF1A-MODY (MODY 3). Pediatrics 133(3):e775–e779PubMedCrossRef Becker M, Galler A, Raile K (2014) Meglitinide analogues in adolescent patients with HNF1A-MODY (MODY 3). Pediatrics 133(3):e775–e779PubMedCrossRef
Zurück zum Zitat Bennett ST, Wilson AJ, Esposito L, Bouzekri N, Undlien DE, Cucca F, Nisticò L, Buzzetti R, Bosi E, Pociot F, Nerup J, Cambon-Thomsen A, Pugliese A, Shield JP, McKinney PA, Bain SC, Polychronakos C, Todd JA (1997) Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group. Nat Genet 17:350–352PubMedCrossRef Bennett ST, Wilson AJ, Esposito L, Bouzekri N, Undlien DE, Cucca F, Nisticò L, Buzzetti R, Bosi E, Pociot F, Nerup J, Cambon-Thomsen A, Pugliese A, Shield JP, McKinney PA, Bain SC, Polychronakos C, Todd JA (1997) Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group. Nat Genet 17:350–352PubMedCrossRef
Zurück zum Zitat Charpentier N, Hartmann R, Deiss D, Danne T, Kordonouri O (2008) Prävalenz und Bedeutung der diabetes-spezifischen Autoantikörper GADA, IA-2A und IAA zum Zeitpunkt der Manifestation eines Typ-1 Diabetes bei 341 Kindern und Jugendlichen. Diabetol Stoffw 3:159–165CrossRef Charpentier N, Hartmann R, Deiss D, Danne T, Kordonouri O (2008) Prävalenz und Bedeutung der diabetes-spezifischen Autoantikörper GADA, IA-2A und IAA zum Zeitpunkt der Manifestation eines Typ-1 Diabetes bei 341 Kindern und Jugendlichen. Diabetol Stoffw 3:159–165CrossRef
Zurück zum Zitat Davis EJ, Kahoska AR, Jefferies C, Dabelea D, Balde N, Ashner P, Craig ME (2018) Definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes 19(Suppl 27):7–19PubMedCrossRefPubMedCentral Davis EJ, Kahoska AR, Jefferies C, Dabelea D, Balde N, Ashner P, Craig ME (2018) Definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes 19(Suppl 27):7–19PubMedCrossRefPubMedCentral
Zurück zum Zitat Drachenberg CB, Klassen DK, Weir MR et al (1999) Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68:396–402PubMedCrossRef Drachenberg CB, Klassen DK, Weir MR et al (1999) Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68:396–402PubMedCrossRef
Zurück zum Zitat Edghill EL, Flanagan SE, Patch AM et al (2008) Insulin mutation screening in 1044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57:1034–1042PubMedCrossRef Edghill EL, Flanagan SE, Patch AM et al (2008) Insulin mutation screening in 1044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57:1034–1042PubMedCrossRef
Zurück zum Zitat Ellard S, Bellanné-Chantelot C, Hattersley AT, European Molecular Genetics Quality Network (EMQN) MODY Group (2008) Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia 51:546–553PubMedPubMedCentralCrossRef Ellard S, Bellanné-Chantelot C, Hattersley AT, European Molecular Genetics Quality Network (EMQN) MODY Group (2008) Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia 51:546–553PubMedPubMedCentralCrossRef
Zurück zum Zitat Fajans SS, Bell GI, Polonsky KS (2001) Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345:971–980PubMedCrossRef Fajans SS, Bell GI, Polonsky KS (2001) Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345:971–980PubMedCrossRef
Zurück zum Zitat Flanagan SE, Edghill EL, Gloyn AL, Ellard S, Hattersley AT (2006) Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype. Diabetologia 49:1190–1197PubMedCrossRef Flanagan SE, Edghill EL, Gloyn AL, Ellard S, Hattersley AT (2006) Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype. Diabetologia 49:1190–1197PubMedCrossRef
Zurück zum Zitat Gloyn AL, Diatloff-Zito C, Edghill EL et al (2006) KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 14:824–830PubMedCrossRef Gloyn AL, Diatloff-Zito C, Edghill EL et al (2006) KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 14:824–830PubMedCrossRef
Zurück zum Zitat Grulich-Henn J, Wagner V, Thon A, Schober E, Marg W, Kapellen TM, Haberland H, Raile K, Ellard S, Flanagan SE et al (2010) Entities and frequency of neonatal diabetes: data from the diabetes documentation and quality management system (DPV). Diabet Med J Br Diabetic Assoc 27(6):709–712CrossRef Grulich-Henn J, Wagner V, Thon A, Schober E, Marg W, Kapellen TM, Haberland H, Raile K, Ellard S, Flanagan SE et al (2010) Entities and frequency of neonatal diabetes: data from the diabetes documentation and quality management system (DPV). Diabet Med J Br Diabetic Assoc 27(6):709–712CrossRef
Zurück zum Zitat Haldorsen IS, Vesterhus M, Raeder H, Jensen DK, Sovik O, Molven A, Njolstad PR (2008) Lack of pancreatic body and tail in HNF1B mutation carriers. Diabet Med J Br Diabetic Assoc 25(7):782–787CrossRef Haldorsen IS, Vesterhus M, Raeder H, Jensen DK, Sovik O, Molven A, Njolstad PR (2008) Lack of pancreatic body and tail in HNF1B mutation carriers. Diabet Med J Br Diabetic Assoc 25(7):782–787CrossRef
Zurück zum Zitat Hattersley A, Bruining J, Shield J, Njolstad P, Donaghue K, International Society for Pediatric and Adolescent Diabetes ISPAD Clinical Practice Consensus Guidelines 2006–2007 (2006) The diagnosis and management of monogenic diabetes in children. Pediatr Diabetes 7:352–360PubMedCrossRef Hattersley A, Bruining J, Shield J, Njolstad P, Donaghue K, International Society for Pediatric and Adolescent Diabetes ISPAD Clinical Practice Consensus Guidelines 2006–2007 (2006) The diagnosis and management of monogenic diabetes in children. Pediatr Diabetes 7:352–360PubMedCrossRef
Zurück zum Zitat Herskowitz-Dumont R, Wolfsdorf JI, Jackson RA, Eisenbarth GS (1993) Distinction between transient hyperglycemia and early insulin-dependent diabetes mellitus in childhood: a prospective study of incidence and prognostic factors. J Pediatr 123:347–354PubMedCrossRef Herskowitz-Dumont R, Wolfsdorf JI, Jackson RA, Eisenbarth GS (1993) Distinction between transient hyperglycemia and early insulin-dependent diabetes mellitus in childhood: a prospective study of incidence and prognostic factors. J Pediatr 123:347–354PubMedCrossRef
Zurück zum Zitat Insel RA, Dunne JL, Atkinson MA et al (2015) Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38:1964–1974PubMedPubMedCentralCrossRef Insel RA, Dunne JL, Atkinson MA et al (2015) Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38:1964–1974PubMedPubMedCentralCrossRef
Zurück zum Zitat International Expert Committee (2009) International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 32:1327–1334 International Expert Committee (2009) International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 32:1327–1334
Zurück zum Zitat Koch C, Rainisio M, Madessani U et al (2001) Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: data from the European Epidemiologic Registry of Cystic Fibrosis. Pediatr Pulmonol 32:343–350PubMedCrossRef Koch C, Rainisio M, Madessani U et al (2001) Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: data from the European Epidemiologic Registry of Cystic Fibrosis. Pediatr Pulmonol 32:343–350PubMedCrossRef
Zurück zum Zitat Lanng S, Thorsteinsson B, Lund-Andersen C, Nerup J, Schiotz PO, Koch C (1994) Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications. Acta Paediatr 83:72–77PubMedCrossRef Lanng S, Thorsteinsson B, Lund-Andersen C, Nerup J, Schiotz PO, Koch C (1994) Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications. Acta Paediatr 83:72–77PubMedCrossRef
Zurück zum Zitat Maes BD, Kuypers D, Messiaen T et al (2001) Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors. Transplantation 72:1655–1661PubMedCrossRef Maes BD, Kuypers D, Messiaen T et al (2001) Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors. Transplantation 72:1655–1661PubMedCrossRef
Zurück zum Zitat Moran A, Pilay K, Becker DJ, Granados A, Hameed S, Acerini CL (2018) Management of cystic fibrosis-related diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines 2018 Compedium. Pediatr Diabetes 19(suppl 27):64–74PubMedCrossRef Moran A, Pilay K, Becker DJ, Granados A, Hameed S, Acerini CL (2018) Management of cystic fibrosis-related diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines 2018 Compedium. Pediatr Diabetes 19(suppl 27):64–74PubMedCrossRef
Zurück zum Zitat Neu A, Feldhahn L, Ehehalt S, Hub R, Ranke MB, DIARY group Baden-Württemberg. (2009) Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0–20 years. Pediatr Diabetes 10(7):468–473 Neu A, Feldhahn L, Ehehalt S, Hub R, Ranke MB, DIARY group Baden-Württemberg. (2009) Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0–20 years. Pediatr Diabetes 10(7):468–473
Zurück zum Zitat O’Riordan SM, Robinson PD, Donaghue KC, Moran A (2008) Management of cystic fibrosis-related diabetes. Pediatr Diabetes 9:338–344PubMedCrossRef O’Riordan SM, Robinson PD, Donaghue KC, Moran A (2008) Management of cystic fibrosis-related diabetes. Pediatr Diabetes 9:338–344PubMedCrossRef
Zurück zum Zitat Owen K, Hattersley AT (2001) Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization. Best Pract Res Clin Endocrinol Metab 15:309–323PubMedCrossRef Owen K, Hattersley AT (2001) Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization. Best Pract Res Clin Endocrinol Metab 15:309–323PubMedCrossRef
Zurück zum Zitat Pearson ER, Flechtner I, Njolstad PR et al (2006) Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 355:467–477PubMedCrossRef Pearson ER, Flechtner I, Njolstad PR et al (2006) Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 355:467–477PubMedCrossRef
Zurück zum Zitat Pihoker C, Gilliam LK, Ellard S, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM et al (2013) Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth. J Clin Endocrinol Metab 98(10):4055–4062PubMedPubMedCentralCrossRef Pihoker C, Gilliam LK, Ellard S, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM et al (2013) Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth. J Clin Endocrinol Metab 98(10):4055–4062PubMedPubMedCentralCrossRef
Zurück zum Zitat Pui CH, Burghen GA, Bowman WP, Aur RJ (1981) Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone. J Pediatr 99:46–50PubMedCrossRef Pui CH, Burghen GA, Bowman WP, Aur RJ (1981) Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone. J Pediatr 99:46–50PubMedCrossRef
Zurück zum Zitat Raeder H, Johansson S, Holm PI et al (2006) Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat Genet 38:54–62PubMedCrossRef Raeder H, Johansson S, Holm PI et al (2006) Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat Genet 38:54–62PubMedCrossRef
Zurück zum Zitat Raile K, Schober E, Konrad K, Thon A, Grulich-Henn J, Meissner T, Wolfle J, Scheuing N, Holl RW, Mellitus DPVItGBCND (2015) Treatment of young patients with HNF1A mutations (HNF1A-MODY). Diabet Med J Br Diabetic Assoc 32(4):526–530CrossRef Raile K, Schober E, Konrad K, Thon A, Grulich-Henn J, Meissner T, Wolfle J, Scheuing N, Holl RW, Mellitus DPVItGBCND (2015) Treatment of young patients with HNF1A mutations (HNF1A-MODY). Diabet Med J Br Diabetic Assoc 32(4):526–530CrossRef
Zurück zum Zitat Reardon W, Ross RJ, Sweeney MG, Luxon LM, Pembrey ME, Harding AE, Trembath RC (1992) Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA. Lancet 340:1376–1379PubMedCrossRef Reardon W, Ross RJ, Sweeney MG, Luxon LM, Pembrey ME, Harding AE, Trembath RC (1992) Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA. Lancet 340:1376–1379PubMedCrossRef
Zurück zum Zitat Rich SS, Onengut-Gumuscu S, Concannon P (2009) Recent progress in the genetics of diabetes. Horm Res 71(Suppl 1):17–23PubMed Rich SS, Onengut-Gumuscu S, Concannon P (2009) Recent progress in the genetics of diabetes. Horm Res 71(Suppl 1):17–23PubMed
Zurück zum Zitat Schatz DA, Bingley PJ (2001) Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT). J Pediatr Endocrinol Metab 14(Suppl 1):619–622PubMed Schatz DA, Bingley PJ (2001) Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT). J Pediatr Endocrinol Metab 14(Suppl 1):619–622PubMed
Zurück zum Zitat Schober E, Rami B, Grabert M, Thon A, Kapellen T, Reinehr T, Holl RW, DP-WIotGWGfPD (2009) Phenotypical aspects of maturity-onset diabetes of the young (MODY diabetes) in comparison with Type 2 diabetes mellitus (T2DM) in children and adolescents: experience from a large multicentre database. Diabetic medicine : a journal of the British Diabetic Association. 26(5):466–473CrossRef Schober E, Rami B, Grabert M, Thon A, Kapellen T, Reinehr T, Holl RW, DP-WIotGWGfPD (2009) Phenotypical aspects of maturity-onset diabetes of the young (MODY diabetes) in comparison with Type 2 diabetes mellitus (T2DM) in children and adolescents: experience from a large multicentre database. Diabetic medicine : a journal of the British Diabetic Association. 26(5):466–473CrossRef
Zurück zum Zitat Shehadeh N, On A, Kessel I et al (1997) Stress hyperglycemia and the risk for the development of type 1 diabetes. J Pediatr Endocrinol Metab 10:283–286PubMedCrossRef Shehadeh N, On A, Kessel I et al (1997) Stress hyperglycemia and the risk for the development of type 1 diabetes. J Pediatr Endocrinol Metab 10:283–286PubMedCrossRef
Zurück zum Zitat Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, Ellard S (2010) Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia 53(12):2504–2508PubMedCrossRef Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, Ellard S (2010) Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia 53(12):2504–2508PubMedCrossRef
Zurück zum Zitat The Expert Committee on the Diagnosis and Classification of Diabetes mellitus (2014) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167CrossRef The Expert Committee on the Diagnosis and Classification of Diabetes mellitus (2014) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167CrossRef
Zurück zum Zitat Valerio G, Franzese A, Carlin E, Pecile P, Perini R, Tenore A (2001) High prevalence of stress hyperglycaemia in children with febrile seizures and traumatic injuries. Acta Paediatr 90:618–622PubMedCrossRef Valerio G, Franzese A, Carlin E, Pecile P, Perini R, Tenore A (2001) High prevalence of stress hyperglycaemia in children with febrile seizures and traumatic injuries. Acta Paediatr 90:618–622PubMedCrossRef
Zurück zum Zitat WHO (World Health Organization), IDF (International Diabetes Federation) (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. World Health Organization, Geneva WHO (World Health Organization), IDF (International Diabetes Federation) (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. World Health Organization, Geneva
Zurück zum Zitat Ziegler AG, Bonifacio E, Group BB S (2012) Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 55:1937–1943PubMedCrossRef Ziegler AG, Bonifacio E, Group BB S (2012) Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 55:1937–1943PubMedCrossRef
Metadaten
Titel
Diabetesformen bei Kindern und Jugendlichen
verfasst von
Olga Kordonouri
Klemens Raile
Copyright-Jahr
2020
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-57309-9_12

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