The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced response — driven partially by the productive infection of antigen-presenting cells — is associated with progression to severe disease.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bhatt, S. et al. Nature 496, 504–507 (2013).
Sridhar, S. et al. N. Engl. J. Med. 379, 327–340 (2018).
Larson, H. J., Hartigan-Go, K. & de Figueiredo, A. Hum. Vaccin. Immunother. 15, 625–627 (2019).
Ghita, L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01654-3 (2023).
Zanini, F. et al. Proc. Natl Acad. Sci. USA 115, E12363–E12369 (2018).
Sangkawibha, N. et al. Am. J. Epidemiol. 120, 653–669 (1984).
Halstead, S. B. & O'Rourke, E. J. J. Exp. Med. 146, 201–217 (1977).
Katzelnick, L. C. et al. Science 358, 929–932 (2017).
Garcia-Bates, T. M. et al. J. Immunol. 190, 80–87 (2013).
Upasani, V. et al. Front. Immunol. 11, 594813 (2020).
Weiskopf, D. et al. Proc. Natl Acad. Sci. USA 110, E2046–E2053 (2013).
Matangkasombut, P. et al. PLoS Negl. Trop. Dis. 8, e2955 (2014).
Rodriguez-Madoz, J. R., Bernal-Rubio, D., Kaminski, D., Boyd, K. & Fernandez-Sesma, A. J. Virol. 84, 4845–4850 (2010).
Robinson, M. L. et al. Sci. Adv. 9, eade7702 (2023).
Acknowledgements
The authors were supported by the Intramural Research Program at the National Institute of Allergy and Infectious Diseases.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Odio, C.D., Aogo, R.A., Lowman, K.E. et al. Severe dengue progression beyond enhancement. Nat Immunol 24, 1967–1969 (2023). https://doi.org/10.1038/s41590-023-01680-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-023-01680-1
This article is cited by
-
Einsatz des neuen Dengue-Impfstoffs Qdenga in Deutschland
Monatsschrift Kinderheilkunde (2024)